Research Applications#

PhaseLab supports several active research areas.

Smith-Magenis Syndrome Gene Therapy#

PhaseLab was originally developed for SMS gene therapy research:

  • RAI1 haploinsufficiency causes circadian disruption

  • CRISPRa can restore RAI1 expression

  • Coherence metrics predict therapeutic efficacy

Key publications and resources:

Protein Folding Coherence#

Phase coherence correlates with protein folding reliability:

  • High coherence proteins fold consistently

  • Low coherence indicates folding instability

  • Applications in protein engineering

Chronotherapy Optimization#

Circadian-aware drug dosing:

  • Multi-tissue circadian models

  • Optimal dosing schedules

  • AAV delivery timing

Research Collaborations#

PhaseLab is used in collaboration with:

  • Quantum computing research (IBM Quantum)

  • Gene therapy development

  • Circadian biology studies

If you’re using PhaseLab in your research, please cite:

@software{phaselab2025,
  title={PhaseLab: Phase-Coherence Analysis Framework},
  author={Vaca, Dylan},
  year={2025},
  url={https://github.com/followthesapper/phaselab},
  version={0.6.1}
}